COVID-19 and metabolic syndrome: could diet be the key?
10 July 2020 - Published in BMJ-Evidence Based Medicine
By Maryanne Demasi, PhD
In the current COVID-19 pandemic, governments mandate social distancing and good hand hygiene, but little attention is paid to the potential impact of diet on health outcomes. Poor diet is the most significant contributor to the burden of chronic, lifestyle-related diseases like obesity, type 2 diabetes and cardiovascular disease.1 As of 30 May 2020, the Centers for Disease Control and Prevention reported that among COVID-19 cases, the two most common underlying health conditions were cardiovascular disease (32%) and diabetes (30%).2 Hospitalisations were six times higher among patients with a reported underlying condition (45.4%) than those without reported underlying conditions (7.6%). Deaths were 12 times higher among patients with reported underlying conditions (19.5%) compared to those without reported underlying conditions (1.6%).2 Two-thirds of people in the UK who have fallen seriously ill with COVID-19 were overweight or obese and 99% of deaths in Italy have been in patients with pre-existing conditions, such as hypertension, diabetes and heart disease.3 These conditions, collectively known as metabolic syndrome, are linked to impaired immune function,4 and more severe symptoms and complications from COVID-19.5
A major factor that drives the pathophysiology of metabolic syndrome is insulin resistance,6 defined as an impaired biological response to insulin, the hormone that regulates blood glucose levels. The dysregulation of blood glucose levels plays an important role in inflammation and respiratory disease. A study of patients with COVID-19 with pre-existing type 2 diabetes showed that those with better regulated blood glucose control fared better than those with poor blood glucose control.7 Specifically, well-controlled blood glucose (glycaemic variability within 3.9–10.0 mmol/L) was associated with reduced medical interventions, major organ injuries and all-cause mortality during hospitalisation, compared with individuals with poorly controlled blood glucose (glycaemic variability exceeding 10.0 mmol/L). Another study showed hospitalised patients with hyperglycaemia treated with insulin infusion had a lower risk of death from COVID-19 than patients without insulin infusion, likely due to reduced inflammatory mediators.8
The most significant factor that determines blood glucose levels is the consumption of dietary carbohydrate, that is, refined carbs, starches and simple sugars. However, the official dietary recommendations of most Western countries advocate for a reduced (low) fat, high-carbohydrate diet, which can exaccerbate hyperglycaemia. These dietary guidelines form the basis of menus in nursing homes and hospital wards where people with COVID-19 and pre-existing metabolic syndrome are undergoing recovery and respite.
The problem is not only confined to nursing homes and hospitals. As people self-isolate at home, many are stockpiling non-perishable staple foods that are cheap such as (carbohydrate-rich) pasta, bread, rice and cereal.9 Our food supply is dominated by highly processed, packaged foods; 71% of available food in the USA is classified as ‘ultra-processed’.10 Food and beverages such as pizza, doughnuts and fruit juices and other sugary drinks are likely to drive hyperinsulinaemia and inflammation, especially in those with metabolic syndrome.
Since the world is facing the rapid transmission of a novel virus, there has been little opportunity to conduct trials on whether patients with COVID-19 fare better on low-carbohydrate diets compared with other diets. However, there is robust evidence that restriction of dietary carbohydrate is a safe and effective way to achieve good glycaemic control and weight loss, and reduce the need for medication in the management of type 2 diabetes.11 12 A systematic review comparing low-carb diets to low-fat diets showed that the low-carb diets were superior for achieving glucose control, as well as for limiting cardiovascular risk factors in the short and long term for people with type 2 diabetes.13
There has been a reluctance to accept the benefits of low-carbohydrate diets, mainly because of the contradiction to official dietary guidelines which recommend that carbohydrates make up between 45 and 65 percent of total daily calories, but significant progress has been made in recent years. For example in 2018, Diabetes Australia released a position statement stating there was reliable evidence that lower carb eating can be safe and useful in reducing blood glucose levels, reducing body weight and managing heart disease risk factors such as raised cholesterol and raised blood pressure.14 Further, in 2019 the American Diabetes Association and in 2020 Diabetes Canada, both endorsed low carbohydrate diets as a viable option to improve glycaemia and the potential to reduce medications for individuals with type 2 diabetes.15 16
There are some medical institutions leading the way. One US-based hospital in West Virginia has answered calls to improve the food environment for its patients by removing all sugary drinks from its vending machines and cafeterias.17 The Jefferson Medical Center is also one of the first hospitals in the USA to offer low-carb meals to its patients with diabetes. Tameside Hospital in Manchester became the first in Britain to remove all added sugar from the meals it prepares for visitors and health service workers and it has taken sugary snacks and fizzy drinks off its menu.18
Restriction of dietary carbohydrates is a simple and safe intervention which results in rapid improvements in glycaemic control and can be implemented alongside usual care in a medical or domestic setting. While the pathophysiology of COVID-19 is multifactorial, insulin resistance is among the strongest determinants of impaired metabolic function. Since 88% of the US population is metabolically unhealthy,19 the extent to which it contributes to the severity of COVID-19 infection is likely to be significant. Therefore, the adoption of dietary advice for people with underlying metabolic syndrome as proposed in the UK,20 should be more widely endorsed by governments and policy makers globally, to mitigate the burden of pre-existing metabolic disease in those who contract COVID-19, now and into the future.
US Burden of Disease Collaborators, Mokdad AH, Ballestros K , et al . The state of US health, 1990-2016: burden of diseases, injuries, and risk factors among US states. JAMA 2018;319:1444–72.doi:10.1001/jama.2018.0158 pmid:http://www.ncbi.nlm.nih.gov/pubmed/29634829 CrossRefPubMedGoogle Scholar
Stokes EK, Zambrano LD, Anderson KN , et al. Coronavirus Disease 2019 Case Surveillance - United States, January 22-May 30, 2020. MMWR Morb Mortal Wkly Rep 2020;69:759–65.doi:10.15585/mmwr.mm6924e2 pmid:http://www.ncbi.nlm.nih.gov/pubmed/32555134 CrossRefPubMedGoogle Scholar
World Obesity. Obesity and COVID-19 policy statement, 2020. Available: http://s3-eu-west-1.amazonaws.com/wof-files/Obesity_and_COVID-19_policy_statement.pdf Google Scholar
Andersen CJ , Murphy KE , Fernandez ML . Impact of obesity and metabolic syndrome on immunity. Adv Nutr 2016;7:66–75.doi:10.3945/an.115.010207 pmid:http://www.ncbi.nlm.nih.gov/pubmed/26773015 Abstract/FREE Full TextGoogle Scholar
Richardson S, Hirsch JS , Narasimhan M , et al . Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the new York City area. JAMA 2020. doi:doi:10.1001/jama.2020.6775 pmid:http://www.ncbi.nlm.nih.gov/pubmed/32320003 Google Scholar
Demasi M , Lustig R , Malhotra A. The cholesterol and calorie hypotheses are both dead — it is time to focus on the real culprit: insulin resistance. Pharmaceutical Journal 2017.Google Scholar
Zhu L, She Z-G , Cheng X , et al. Association of blood glucose control and outcomes in patients with COVID-19 and pre-existing type 2 diabetes. Cell Metab 2020;31:1068–77.doi:10.1016/j.cmet.2020.04.021 pmid:http://www.ncbi.nlm.nih.gov/pubmed/32369736 CrossRefPubMedGoogle Scholar
Sardu C, D'Onofrio N, Balestrieri ML , et al. Outcomes in patients with hyperglycemia affected by COVID-19: can we do more on glycemic control? Diabetes Care 2020;43:1408–15.doi:10.2337/dc20-0723 pmid:http://www.ncbi.nlm.nih.gov/pubmed/32430456 Abstract/FREE Full TextGoogle Scholar
Terazono E. Wheat prices rise as shoppers rush to stockpile pasta and flour. Financial Times 2020.Google Scholar
Baldridge AS, Huffman MD, Taylor F , et al The Healthfulness of the US packaged food and beverage supply: a cross-sectional study. Nutrients 2019;11:1704. doi:10.3390/nu11081704 pmid:http://www.ncbi.nlm.nih.gov/pubmed/31344845 CrossRefPubMedGoogle Scholar
Feinman RD, Pogozelski WK, Astrup A , et al Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition 2015;31:1–13.doi:10.1016/j.nut.2014.06.011 pmid:http://www.ncbi.nlm.nih.gov/pubmed/25287761 CrossRefPubMedGoogle Scholar
McKenzie AL, Hallberg SJ , Creighton BC , et al A novel intervention including individualized nutritional recommendations reduces hemoglobin A1c level, medication use, and weight in type 2 diabetes. JMIR Diabetes 2017;2:e5. doi:10.2196/diabetes.6981 pmid:http://www.ncbi.nlm.nih.gov/pubmed/30291062 CrossRefPubMedGoogle Scholar
van Zuuren EJ, Fedorowicz Z, Kuijpers T , et al Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including grade assessments. Am J Clin Nutr 2018;108:300–31.doi:10.1093/ajcn/nqy096 pmid:http://www.ncbi.nlm.nih.gov/pubmed/30007275 CrossRefPubMedGoogle Scholar
Diabetes Australia. Position statement. low carbohydrate eating for people with diabetes, 2018. Available: https://static.diabetesaustralia.com.au/s/fileassets/diabetes-australia/8b4a8a54-f6b0-4ce6-bfc2-159686db7983.pdf Google Scholar
Diabetes Canada position statement on low-carbohydrate diets for adults with diabetes: a rapid review. Can J Diabetes 2020;44:295–9.doi:10.1016/j.jcjd.2020.04.001 pmid:http://www.ncbi.nlm.nih.gov/pubmed/32475469 CrossRefPubMedGoogle Scholar
Evert AB, Dennison M, Gardner CD , et al Nutrition therapy for adults with diabetes or prediabetes: a consensus report. Diabetes Care 2019;42:731–54.doi:10.2337/dci19-0014 pmid:http://www.ncbi.nlm.nih.gov/pubmed/31000505 FREE Full TextGoogle Scholar
Cucuzzella M. Get sugary drinks out of hospitals, 2018. Available: https://www.salon.com/2018/06/03/get-sugary-drinks-out-of-hospitals/ Google Scholar
Marsh S Nhs Hospital bans sugar from its meals to tackle staff obesity, 2018. Available: https://www.theguardian.com/society/2018/jan/09/nhs-hospital-bans-sugar-from-its-meals-to-tackle-staff-obesity Google Scholar
Araújo J, Cai J ,Stevens J. Prevalence of optimal metabolic health in American adults: National health and nutrition examination survey 2009-2016. Metab Syndr Relat Disord 2019;17:46–52.doi:10.1089/met.2018.0105 pmid:http://www.ncbi.nlm.nih.gov/pubmed/30484738 CrossRefPubMedGoogle Scholar
Gallagher P Coronavirus latest: ‘Public health revolution’ needed to combat ‘root cause’ of Covid-19 deaths, 2020. Available: https://inews.co.uk/news/coronavirus-public-health-revolution-matt-hancock-aseem-malhotra-covid-19-deaths-428861 Google Scholar
Contributors MD is the sole author of this article.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.