MD REPORTS

MD REPORTS

MIT researchers uncover potential safety signal in CDC vaccine database

Nearly 2% of V-SAFE participants reported health deterioration lasting at least three months, which they attributed to Covid vaccination. The CDC has yet to investigate.

Maryanne Demasi, PhD's avatar
Maryanne Demasi, PhD
Aug 26, 2026
∙ Paid

A new preprint analysis from MIT researchers examines data from the CDC’s V-SAFE system—the smartphone app used to actively monitor health outcomes following Covid-19 vaccination.

Led by Retsef Levi and Nelson Lu, the analysis of responses from nearly 10 million people aged 16 and older found that 185,285 individuals (1.87%) reported health deterioration lasting three months or longer and attributed that decline to Covid vaccination.

Roughly half of this group—about 1% of all V-SAFE participants—described their outcomes as severe, including inability to work or perform daily activities, hospitalisation, or potentially disabling symptoms.

doi.org/10.21203/rs.3.rs-10768889/v1

The V-SAFE survey reports, collected between December 2020 and mid-2023, remained largely inaccessible to independent researchers until FOIA litigation by Informed Consent Action Network forced their release.

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