I think the budget spent on these drugs in the UK is significant. Maybe it would be better used to improve diet by reducing refined carbohydrates and unhealthy seed oils in our diet. A study is needed which uses real end points (like death or stroke) and reports absolute risk reduction. Has this been done?
I was thinking more of a study of healthy people (with high choloeserol) with one arm testing dietary change (as I described) and the other statins (at the dose usually advised) with the hard endpoints you describe.
I totally agree with Demasi’s point on statins. Basically, I think the function of statins are as anti-inflammatory, and there are better safer options in that regard. More info is needed IMO to improve methylization needed to prevent damage by homocysteine. Anyone know of updated info on that? Then, folks who naturally have high cholesterol levels (as in Baltic countries) can relax a little and focus on what really helps.
I think the budget spent on these drugs in the UK is significant. Maybe it would be better used to improve diet by reducing refined carbohydrates and unhealthy seed oils in our diet. A study is needed which uses real end points (like death or stroke) and reports absolute risk reduction. Has this been done?
The study I publish here, reanalysed all the statin trials, focused on hard endpoints like MI, stroke & death, and looked at absolute risk reduction.
I was thinking more of a study of healthy people (with high choloeserol) with one arm testing dietary change (as I described) and the other statins (at the dose usually advised) with the hard endpoints you describe.
Ah, ok…. I don’t know of any.
Good job. I remember the good old days of ABC tv when Catalyst published a story questioning the over prescription of statins.
Yeah, I try to forget those days 😂
Thank you
I totally agree with Demasi’s point on statins. Basically, I think the function of statins are as anti-inflammatory, and there are better safer options in that regard. More info is needed IMO to improve methylization needed to prevent damage by homocysteine. Anyone know of updated info on that? Then, folks who naturally have high cholesterol levels (as in Baltic countries) can relax a little and focus on what really helps.
I found a good review of homocysteine the other day https://www.frontiersin.org/articles/10.3389/fcvm.2022.1109445/full#:~:text=5.-,Mechanism%20of%20endothelial%20injury%20by%20homocysteine,and%20oxidative%20stress%2C%20cellular%20hypomethylation I know that Malcolm Kendrick implicates it by saying that homocysteine blocks Nitric Oxide and if you block Nitric Oxide you lose a lot of your anticoagulant protection and you then can develop blood clots.